Vitamin D and Immune Function – Review July 2013

Nutrients 2013, 5(7), 2502-2521; doi:10.3390/nu5072502 (doi registration under processing)
Barbara Prietlemail, Gerlies Treiberemail, Thomas R. Pieberemail and Karin Amrein karin.amrein at medunigraz.at
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
(This article belongs to the Special Issue Nutrients and Immune Function)

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.

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Type 1 Diabetes - variety of forms of vitamin D

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Possible vitamin D interaction with T cells

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Vitamin D treatments for kidney

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